Building renal tubular organoids in vitro

Generation of renal tubular organoids from adult SOX9+ kidney progenitor cells

Adult SOX9-positive kidney progenitor cells formed renal tubular organoids under specific in vitro culture conditions. Cell types were analyzed by single-cell sequencing.

What this study examined

• Published 2023-11-23 · Life Medicine 2(6), lnad047
• Cells showed a tendency toward renal tubular differentiation; they did not differentiate into glomerular cells
• The organoids were not fully mature and lacked blood circulation; they were not complete functional kidneys

Why the study matters

Taking regeneration research into three dimensions: adult kidney progenitor cells self-organize into renal tubular organoids.