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EVIDENCE LIBRARY

Ingredients, user feedback
And research evidence

Explore ingredient names, six kidney research papers and their original figures

01 / INGREDIENT RECORDS

Begin with ingredient identity

INCI · International Nomenclature of Cosmetic Ingredients

Human Kidney Tubule
Epithelial Stem Cell Extract

Human Kidney Tubule Epithelial Stem Cell Extract

Ingredient ID
37564

JCIA · Japanese ingredient labeling name

ヒト腎尿細管上皮
幹細胞エキス

Human Kidney Tubule Epithelial Stem Cell Extract

Acceptance number
22788
View names and reference numbers

02 / PEER-REVIEWED RESEARCH

Six papers, six perspectives in depth

Six studies examine cells, animal models, human samples and renal tubular organoids. Read the papers and view their original figures.

01

2018 · Life Sci

Cellular clues to endogenous repair

In a mouse model of partial nephrectomy, Notch signaling was involved in activating Sox9-positive cells, and renal tubular repair was observed.

Animal model · Repair mechanismsRead the study ↗
02

2021 · Protein Cell

Kidney progenitors from human urine

A single-cell atlas of adult urine identified SOX9-positive kidney progenitor cells. After intrarenal transplantation, human-derived cell clones formed luminal structures with some renal tubular features in injured immunodeficient mice.

Human samples · Single-cell sequencing and mouse transplantationRead the study ↗
03

2023 · Cell Prolif

How cells communicate repair signals

SOX9-positive renal epithelial cells showed secretion-related characteristics in injury models. Cell implantation or administration of conditioned medium promoted repair in mice, with S100A9 identified as a candidate key secreted factor.

Basic research · Cell-secreted factorsRead the study ↗
04

2023 · Life Med

Building renal tubular organoids in vitro

Adult SOX9-positive kidney progenitor cells formed renal tubular organoids under specific in vitro culture conditions. Cell types were analyzed by single-cell sequencing.

In vitro research · Renal tubular organoidsRead the study ↗
05

2023 · Clin Kidney J

Urine cell atlas and immune differences

An observational single-cell analysis of urine from healthy individuals and patients with different membranous nephropathy outcomes identified differences in macrophage origins and functions.

Human samples · Observational studyRead the study ↗
06

2023 · Theranostics

Tracing the cellular origins of renal tubular regeneration

Lineage tracing and single-cell sequencing in a mouse model of severe acute kidney injury supported the contribution of WT1-positive glomerular parietal epithelial progenitor cells to proximal tubule regeneration.

Animal model · Lineage tracingRead the study ↗

03 / RESEARCH IMAGES

See the research process

From tissue sections to cell culture, figures retain their full visual content and original labels. Select an image to explore the details.

Tissue and renal function measures after partial nephrectomy in mice · Original paper
SOX9-positive cells and the injury repair process · Original paper
Notch pathway expression and intervention experiments · Original paper
Culture, transcriptomic and genetic stability analyses of human urine-derived progenitor cells · Original paper
Tubular structures and dextran uptake experiments after progenitor cell transplantation · Original paper

Figures are excerpts from the original papers in Life Sciences (2018) and Protein & Cell (2021). The Protein & Cell figures are credited to Yujia Wang et al. under CC BY 4.0. Full captions and author lists are available in the respective papers.

04 / CLINICAL TRANSLATION

Research and medicine move forward

KIDNEY · Kidney progenitor cells

From research to clinical exploration

The REGEND003 kidney progenitor cell project has entered a registered Phase I clinical study. It plans to enroll 15 people with type 2 diabetes and chronic kidney disease, focusing on safety and tolerability, and is conducted by a research team at a leading hospital in Asia.

Registry updated: 2026.03.17 · Intrarenal cell transplantation study

View clinical registration NCT07275788

PLATFORM · Translating organ regeneration

Medical translation in Hainan

According to Regend, its REGEND001 autologous lung progenitor cell project has entered medical application and fee-based services at Ruijin Hospital Hainan in Boao Lecheng, Hainan.

Read the project team’s public information

BIO-PILOT ESSENCE / 003

Kidney-derived gel essence
Coming soon

1g × 7 applicators · Made in Japan

View product

USER-REPORTED RESULTS

Brand user survey
Sleep and energy feedback

44%

Reported better sleep quality

Experiences of deep sleep and waking during the night

62%

Reported improved energy and stamina

Perceived fatigue and sustained activity

26%

Reported improved male sexual wellbeing

Feedback on quality of sex life

50%

Reported improved wellbeing through women’s life stages

Feedback related to menopause and hormones

Brand user survey, combined sample n=100. Percentages show respondents who reported an improvement.

Results are self-reported. Individual experiences may vary.

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