REGENERATIVE SCIENCE / EXOSOME BETA

Kidney longevityFrom regeneration science

Bio-Pilot Essence · Kidney-Derived Gel Essence

Focused on sleep quality, daytime energy and midlife wellbeing
Connecting research and product through an exclusive kidney-derived ingredient

Explore the gel View user feedback

44%Reported better sleep quality62%Reported improved energy and stamina

Brand user survey · Combined sample n=100 · Kidney longevity is a research direction

Bio-Pilot Essence transparent, needle-free inner applicator

003 / BIO-PILOT ESSENCEMADE IN JAPAN
1g × 7

Kidney longevity

Research into kidney progenitor cells, repair mechanisms and organoids

Research direction

Exclusive kidney ingredient

INCI 37564 · JCIA 22788

Ingredient naming records

Six research papers

From a single-cell atlas of urine to renal tubular regeneration

Papers and original figures

Sleep and energy

User feedback on sleep, energy and wellbeing

Four everyday scenarios

01 / USER-REPORTED RESULTS

What changed after use
In users’ own accounts

44%

Reported better sleep quality

Experiences of deep sleep and waking during the night

62%

Reported improved energy and stamina

Perceived fatigue and sustained activity

26%

Reported improved male sexual wellbeing

Feedback on quality of sex life

50%

Reported improved wellbeing through women’s life stages

Feedback related to menopause and hormones

Brand user survey, combined sample n=100. Percentages show respondents who reported an improvement.

Results are self-reported. Individual experiences may vary.

View survey results

02 / REGENERATIVE SCIENCE

From identifying cells
To advancing renal tubular regeneration research

The first single-cell atlas of adult human urine identified kidney progenitor cells that could be cultured. Renal tubular organoids were then built in vitro to further investigate tissue repair.

Kidney progenitor cells
Identify · Culture · Build · Validate

Identifying cells

Analysis of 1,010 urine cells identified 7 cell populations

Single-cell atlas

Repair signals

Studying SOX9-positive cells and secreted factors

Mechanisms of action

Building in vitro

Forming renal tubular organoids from adult kidney progenitor cells

Organoid research

Tracing regeneration

Tracing the cellular origins of proximal tubule repair

Cell lineage

At the frontier of global researchOriginal ingredient developmentPrecision product development in Japan

03 / BIO-PILOT ESSENCE

A kidney-derived ingredient
In a nightly application

Bio-Pilot Essence presentation box with inner applicators

003 / KIDNEY GEL

Improve sleep
Restore daytime energy

Formulated with Human Kidney Tubule Epithelial Stem Cell Extract
Topical gel · Apply nightly before bed · 1g × 7 applicators

View product

Traceable ingredient naming

International ingredient ID 37564 · Japanese acceptance number 22788

INCI × JCIA

User-reported improvements

User feedback on sleep, energy and intimacy

Feedback and data

Apply to the inner wrists

Dispense, then gently spread between both wrists; follow the illustrated guide

View illustrated guide

Individual rendering of the latest Bio-Pilot Essence presentation box

BIO-PILOT ESSENCE / 003

Exclusive kidney ingredient
Apply nightly before bed

Gel essence · 1g × 7 applicators · Made in Japan

View full product information

04 / EVERYDAY MOMENTS

What improves
See it in everyday life

SLEEP QUALITY

Sleep more deeply
Wake more clearly

Shallow sleep, waking at night and morning fatigue are common concerns among users. In the brand user survey, 44% reported better sleep quality.

View user feedback ↗

INTIMACY

Intimacy
Deserves energy

Explore user feedback on energy and intimacy with a partner, including male intimate wellbeing and women’s life-stage concerns.

View user feedback ↗

DAYTIME ENERGY

Demanding work
Calls for energy

Stay engaged through a busy working day. In the brand user survey, 62% reported improved energy and stamina.

View user feedback ↗

PHYSICAL ENDURANCE

More stamina
For what you love

Sport and a busy day both call for stamina. In the brand user survey, 62% reported improved energy and stamina.

View user feedback ↗

05 / HOW TO USE

Every night before bed
Apply to the inner wrists

Remove the cap

Clean your hands and remove the cap

Apply to the inner wrist

Press with one hand to dispense onto the inner wrist of the other

Gently spread between wrists

Bring the inner wrists together and gently spread the gel

Play all steps

06 / ORIGINAL INGREDIENT

INCI × JCIA
Kidney-derived ingredient naming records

INCI · International Nomenclature of Cosmetic Ingredients

Human Kidney Tubule
Epithelial Stem Cell Extract

Human Kidney Tubule Epithelial Stem Cell Extract

Ingredient ID: 37564

JCIA · Japanese ingredient labeling name

ヒト腎尿細管上皮
幹細胞エキス

Human Kidney Tubule Epithelial Stem Cell Extract

Acceptance number: 22788

View ingredient profile

07 / EVIDENCE

Research findings
Read the papers and original figures

2018 · Life Sci

Cellular clues to endogenous repair

In a mouse model of partial nephrectomy, Notch signaling was involved in activating Sox9-positive cells, and renal tubular repair was observed.

Animal model · Repair mechanismsRead the study ↗

2021 · Protein Cell

Kidney progenitors from human urine

A single-cell atlas of adult urine identified SOX9-positive kidney progenitor cells. After intrarenal transplantation, human-derived cell clones formed luminal structures with some renal tubular features in injured immunodeficient mice.

Human samples · Single-cell sequencing and mouse transplantationRead the study ↗

View all six papers